For all the hype, being creative can be tough. Despite the all the benefits of a creative mind, it comes with some challenges as well.
Creative people are more vulnerable
Creative people tend to be open to new experiences and tolerant of ambiguity; due to this perspective, they are constantly seeing life in new, novel ways. Though it is this ability that enables them to make new discoveries and generate new ideas, it also tends to lead to feelings of depression or social alienation. Where less creative people respond more quickly to authority, the creative’s ill-defined, fluid perspective makes it more difficult to relate to the rest of the outside world; they may have to deal with criticism and rejection for being too unconventional.
Creative minds have difficulty filtering sensory imput
Creatives are more at risk for mental illness which seems to stem from a problem filtering out stimuli entering the brain. Though this characteristic may be useful making novel connections, it may cause distractions that cause them to become more introverted.
Read Susan Biali’s full article here: http://www.psychologytoday.com/blog/prescriptions-life/201204/little-weird-prone-depression-blame-your-creative-brain
And for more information on the ups and downs of the creative mind, refer to The Creative Brain: The Science of Genius